Table 1 Immunohistochemical characterization of epidermal and oral mucosal derived ePUKs

Ki 67³

66 ± 8%

25 – 50%

cell cycle related nuclear protein expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase) but absent in resting (G0) cells

P63⁴

64 ± 0%

20 – 75%

expressed in the epithelial basal cells of different organs and have been considered as possible markers of stem cells/reserve cells

K14⁵

75 ± 8

50 – 100%

expressed in basal cells of epithelium

K10⁵

16 ± 6%

20 – 30%

seen in all suprabasal cell layers including stratum corneum

loricrin

4 ± 2%⁶

0%⁷

major protein component of the cornified cell envelope found in terminally differentiated epidermal cells but not oral non-keratinized mucosal cells

involucrin⁸

88 ± 6 but very light and diffuse

100% light and diffuse

Found in terminally differentiated keratinocytes

α6β4integrin⁹

trace

Trace

α6 β4 complex receptor for laminin and It is expressed on epithelial basal cells

CD71⁷

trace

0%

α6 β4integrin^bright/CD71^dim is reported to be a marker of epithelial stem cells