Table 3 Sample size estimations
Outcome | Minimum relevant difference | Risk of type I error | Risk of type II error | Total number of participants needed |
|---|---|---|---|---|
Total sick days | 5 days (SD* 21 days) | 1.67% | 20% | 742 |
DLQI† | 1.2 points (SD 4.8 points) | 1.67% | 20%‡ | 672 |
Subjective assessment of hand eczema severity | 20% risk reduction from 60% event rate in the control group | 1.67% | 20%§ | 720 |