| |
Baseline1
| | |
1-4 weeks
| | |
5-8 weeks
| | |
9-12 weeks
| | |
Mean change2
| | | |
|---|
| |
Mean
|
(SD)
|
N
|
Mean
|
(SD)
|
N
|
Mean
|
(SD)
|
N
|
Mean
|
(SD)
|
N
|
Mean
|
95% CI3
|
N
|
p3
|
|---|
|
Emollient Use (g/wk)
4
|
|
Daily diary
|
-
| | |
165.2
|
(96.4)
|
135
|
168.4
|
(113.2)
|
135
|
167.8
|
(109.5)
|
135
|
87.6
|
(81.9 to 119.5)
|
132
|
0.001
|
|
Time to use
|
79.2
|
(79.2)
|
132
|
173.5
|
(114.3)
|
122
|
195.2
|
(112.1)
|
128
|
197.4
|
(106.5)
|
129
|
110.0
|
(94.6 to 131.3)
|
115
|
0.001
|
|
Severity Scores
|
|
POEM5
|
11.34
|
(6.27)
|
135
|
7.52
|
(5.71)
|
135
|
5.50
|
(5.05)
|
135
|
4.85
|
(5.04)
|
135
|
-5.38
|
(-6.41 to -4.36)
|
135
|
0.001
|
|
PEST6
|
2.26
|
(0.81)
|
135
|
1.82
|
(0.73)
|
135
|
1.59
|
(0.78)
|
135
|
1.53
|
(0.68)
|
135
|
-0.61
|
(-0.75 to -0.47)
|
135
|
0.001
|
|
Individual Scores
|
|
Dryness [A] 7
|
5.66
|
(1.97)
|
135
|
4.09
|
(2.38)
|
135
|
3.22
|
(2.45)
|
135
|
2.86
|
(2.39)
|
135
|
-2.28
|
(-2.67 to -1.90)
|
135
|
0.001
|
|
Redness [B] 7
|
4.12
|
(2.44)
|
135
|
2.74
|
(2.42)
|
135
|
1.95
|
(2.18)
|
135
|
1.82
|
(2.13)
|
135
|
-1.95
|
(-2.37 to -1.53)
|
135
|
0.001
|
|
Itchiness [C] 7
|
4.73
|
(2.54)
|
135
|
3.38
|
(2.56)
|
135
|
2.63
|
(2.67)
|
135
|
2.37
|
(2.53)
|
135
|
-1.94
|
(-2.36 to -1.52)
|
135
|
0.001
|
|
[A] + [B] + [C]
|
14.51
|
(5.64)
|
135
|
10.21
|
(6.35)
|
135
|
7.79
|
(6.24)
|
135
|
7.04
|
(6.24)
|
135
|
-6.17
|
(-7.17 to -5.20)
|
135
|
0.001
|
|
Sleep disturbance 7
|
2.36
|
(2.44)
|
135
|
1.49
|
(2.12)
|
135
|
0.98
|
(1.62)
|
135
|
0.80
|
(1.59)
|
135
|
-1.27
|
(-1.68 to -0.85)
|
135
|
0.001
|
|
Bleeding7
|
1.34
|
(1.99)
|
135
|
0.68
|
(1.35)
|
135
|
0.42
|
(1.05)
|
135
|
0.33
|
(1.03)
|
135
|
-0.86
|
(-1.18 to -0.56)
|
135
|
0.001
|
|
Weeping or oozing7
|
0.86
|
(1.74)
|
135
|
0.40
|
(1.15)
|
135
|
0.24
|
(0.87)
|
135
|
0.18
|
(0.76)
|
135
|
-0.59
|
(-0.87 to -0.35)
|
135
|
0.001
|
|
Cracking7
|
2.44
|
(2.50)
|
135
|
1.41
|
(1.90)
|
135
|
1.02
|
(1.79)
|
135
|
0.89
|
(1.81)
|
135
|
-1.34
|
(-1.77 to -0.97)
|
135
|
0.001
|
|
Flaking7
|
2.26
|
(2.63)
|
135
|
1.37
|
(1.96)
|
135
|
0.80
|
(1.47)
|
135
|
0.76
|
(1.57)
|
135
|
-1.28
|
(-1.69 to -0.85)
|
135
|
0.001
|
|
Roughness7
|
5.49
|
(2.07)
|
135
|
4.25
|
(2.40)
|
135
|
3.32
|
(2.54)
|
135
|
3.56
|
(2.10)
|
135
|
-1.93
|
(-2.33 to -1.55)
|
135
|
0.001
|
|
Severity7
|
4.65
|
(5.16)
|
135
|
2.49
|
(3.86)
|
135
|
1.68
|
(3.17)
|
135
|
1.39
|
(3.02)
|
135
|
-2.80
|
(-3.63 to -2.03)
|
135
|
0.001
|
|
Other
|
|
Parental Control8
|
3.30
|
(0.99)
|
135
|
4.43
|
(0.66)
|
134
|
4.61
|
(0.57)
|
135
|
4.81
|
(0.41)
|
135
|
1.32
|
(1.16 to 1.48)
|
134
|
0.001
|
|
GP Visits1
|
1.90
|
(2.13)
|
135
|
0.46
|
(0.54)
|
135
|
0.25
|
(0.44)
|
135
|
0.13
|
(0.36)
|
135
|
-1.06
|
(-1.49 to -0.70)
|
135
|
0.002
|
|
Steroid Prescribed (%)9
|
51/135
|
(37.8%)
|
73/135
|
(54.1%)
|
82/135
|
(60.7%)
|
82/135
|
(60.7)%
|
20.8%
|
(8.9% to 32.1%)
|
135
|
0.001
|
-
1 Weeks -2 to 0, except GP visits which included the previous 12 weeks to week 0.
-
2 The mean change is the average of the programme period scores minus the baseline period score in subjects with complete data.
-
3 Estimated by bootstrapping with 1,000 replications.
-
4 Emollient use was estimated using two methods: the time to use a reported weight of emollient (500 g); and, a daily diary record of counts of pumps of emollient used by weight; – the latter method was not available for the baseline period.
-
5 POEM score from 0 to 28, including seven signs of eczema at four levels of frequency in the past week at the end of each period.
-
6 PEST score, the child’s unhappiness with eczema: score 1 (not at all) to 5 (very unhappy), daily diary score averaged over each period.
-
7 Number of days in the previous week has the child had this sign of eczema: score 0 to 7 days, at the end of each period.
-
8 Parental confidence in managing the child’s eczema: score 1 (not being in control) to 5 (being totally in control), at the end of each period.
-
9 Proportion of children prescribed topical corticosteroids during each period.
