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Table 1 Changes in emollient use and measures of eczema severity

From: Improved emollient use reduces atopic eczema symptoms and is cost neutral in infants: before-and-after evaluation of a multifaceted educational support programme

  Baseline1    1-4 weeks    5-8 weeks    9-12 weeks    Mean change2    
  Mean (SD) N Mean (SD) N Mean (SD) N Mean (SD) N Mean 95% CI3 N p3
Emollient Use (g/wk) 4
 Daily diary -    165.2 (96.4) 135 168.4 (113.2) 135 167.8 (109.5) 135 87.6 (81.9 to 119.5) 132 0.001
 Time to use 79.2 (79.2) 132 173.5 (114.3) 122 195.2 (112.1) 128 197.4 (106.5) 129 110.0 (94.6 to 131.3) 115 0.001
Severity Scores
 POEM5 11.34 (6.27) 135 7.52 (5.71) 135 5.50 (5.05) 135 4.85 (5.04) 135 -5.38 (-6.41 to -4.36) 135 0.001
 PEST6 2.26 (0.81) 135 1.82 (0.73) 135 1.59 (0.78) 135 1.53 (0.68) 135 -0.61 (-0.75 to -0.47) 135 0.001
Individual Scores
 Dryness [A] 7 5.66 (1.97) 135 4.09 (2.38) 135 3.22 (2.45) 135 2.86 (2.39) 135 -2.28 (-2.67 to -1.90) 135 0.001
 Redness [B] 7 4.12 (2.44) 135 2.74 (2.42) 135 1.95 (2.18) 135 1.82 (2.13) 135 -1.95 (-2.37 to -1.53) 135 0.001
 Itchiness [C] 7 4.73 (2.54) 135 3.38 (2.56) 135 2.63 (2.67) 135 2.37 (2.53) 135 -1.94 (-2.36 to -1.52) 135 0.001
 [A] + [B] + [C] 14.51 (5.64) 135 10.21 (6.35) 135 7.79 (6.24) 135 7.04 (6.24) 135 -6.17 (-7.17 to -5.20) 135 0.001
 Sleep disturbance 7 2.36 (2.44) 135 1.49 (2.12) 135 0.98 (1.62) 135 0.80 (1.59) 135 -1.27 (-1.68 to -0.85) 135 0.001
 Bleeding7 1.34 (1.99) 135 0.68 (1.35) 135 0.42 (1.05) 135 0.33 (1.03) 135 -0.86 (-1.18 to -0.56) 135 0.001
 Weeping or oozing7 0.86 (1.74) 135 0.40 (1.15) 135 0.24 (0.87) 135 0.18 (0.76) 135 -0.59 (-0.87 to -0.35) 135 0.001
 Cracking7 2.44 (2.50) 135 1.41 (1.90) 135 1.02 (1.79) 135 0.89 (1.81) 135 -1.34 (-1.77 to -0.97) 135 0.001
 Flaking7 2.26 (2.63) 135 1.37 (1.96) 135 0.80 (1.47) 135 0.76 (1.57) 135 -1.28 (-1.69 to -0.85) 135 0.001
 Roughness7 5.49 (2.07) 135 4.25 (2.40) 135 3.32 (2.54) 135 3.56 (2.10) 135 -1.93 (-2.33 to -1.55) 135 0.001
 Severity7 4.65 (5.16) 135 2.49 (3.86) 135 1.68 (3.17) 135 1.39 (3.02) 135 -2.80 (-3.63 to -2.03) 135 0.001
Other
 Parental Control8 3.30 (0.99) 135 4.43 (0.66) 134 4.61 (0.57) 135 4.81 (0.41) 135 1.32 (1.16 to 1.48) 134 0.001
 GP Visits1 1.90 (2.13) 135 0.46 (0.54) 135 0.25 (0.44) 135 0.13 (0.36) 135 -1.06 (-1.49 to -0.70) 135 0.002
 Steroid Prescribed (%)9 51/135 (37.8%) 73/135 (54.1%) 82/135 (60.7%) 82/135 (60.7)% 20.8% (8.9% to 32.1%) 135 0.001
  1. 1 Weeks -2 to 0, except GP visits which included the previous 12 weeks to week 0.
  2. 2 The mean change is the average of the programme period scores minus the baseline period score in subjects with complete data.
  3. 3 Estimated by bootstrapping with 1,000 replications.
  4. 4 Emollient use was estimated using two methods: the time to use a reported weight of emollient (500 g); and, a daily diary record of counts of pumps of emollient used by weight; – the latter method was not available for the baseline period.
  5. 5 POEM score from 0 to 28, including seven signs of eczema at four levels of frequency in the past week at the end of each period.
  6. 6 PEST score, the child’s unhappiness with eczema: score 1 (not at all) to 5 (very unhappy), daily diary score averaged over each period.
  7. 7 Number of days in the previous week has the child had this sign of eczema: score 0 to 7 days, at the end of each period.
  8. 8 Parental confidence in managing the child’s eczema: score 1 (not being in control) to 5 (being totally in control), at the end of each period.
  9. 9 Proportion of children prescribed topical corticosteroids during each period.