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Table 1 Allele frequencies of LAMA3, LAMB3 and LAMC2 polymorphisms in AD patients and controls

From: Association of variation in the LAMA3 gene, encoding the alpha-chain of laminin 5, with atopic dermatitis in a German case–control cohort

Gene

SNP

Location

Amino acid exchange

MAF in AD patients

MAF in controls

Uncorrected p-value

Corrected p-value*

LAMA3 18q11.2

rs7238623

5′UTR (ANKRD29)

-

0.107

0.083

0.123

n.s.

 

rs8096061

5′UTR (ANKRD29)

-

0.036

0.044

0.441

n.s.

 

rs1613739

5′UTR (ANKRD29)

-

0.143

0.200

0.003

0.087

 

rs12960692

5′UTR

-

0.439

0.454

0.568

n.s.

 

rs8083184

5′UTR

-

0.297

0.386

0.0003

0.0087

 

rs1711450

5′UTR

-

0.319

0.410

0.0003

0.0087

 

rs1711451

Intron 1

-

0.336

0.408

0.005

0.145

 

rs4387667

Intron 2

-

0.336

0.408

0.005

0.145

 

rs2337187

Intron 2

-

0.250

0.325

0.001

0.029

 

rs1316950

Intron 2

-

0.331

0.407

0.003

0.087

 

rs4044148

Intron 12

-

0.234

0.395

0.007

0.203

 

rs1262340

Intron 44

-

0.143

0.196

0.006

0.174

 

rs734731

Intron 55

-

0.079

0.104

0.096

n.s.

 

rs1541836

Intron 59

-

0.086

0.106

0.195

n.s.

 

rs1786310

Intron 62

-

0.076

0.103

0.047

n.s.

 

rs1154232

Exon 65

Asn2815Lys

0.187

0.225

0.069

n.s.

 

rs2288592

Intron 69

-

0.278

0.345

0.005

0.145

LAMB3 1q32.2

rs2566

3′UTR

-

0.283

0.271

0.611

n.s.

 

rs2009292

Intron 18

-

0.323

0.336

0.617

n.s.

 

rs3179860

Exon 18

Leu891Leu

0.161

0.144

0.375

n.s.

 

rs12748250

Exon 17

Met852Leu

0.167

0.150

0.361

n.s.

 

rs2072938

Intron 11

-

0.172

0.174

0.901

n.s.

 

rs4844863

Intron 8

-

0.157

0.160

0.889

n.s.

 

rs2236891

Intron 8

-

0.129

0.101

0.094

n.s.

 

rs2236892

Intron 8

-

0.165

0.178

0.517

n.s.

LAMC2 1q25.3

rs483783

Intron 1

-

0.490

0.467

0.362

n.s.

 

rs601508

Intron 1

-

0.476

0.440

0.158

n.s.

 

rs2274980

Exon 3

Ser99Ser

0.166

0.173

0.723

n.s.

 

rs11586699

Exon 3

Thr124Met

0.077

0.062

0.263

n.s.

  1. *after Bonferroni correction for 29 SNPs; n.s.: not significant; bold: significant results.