Skip to main content
Figure 3 | BMC Dermatology

Figure 3

From: Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing

Figure 3

Expression of Delta-1 , Notch-1 and Fringe genes in four different types of basal cell carcinoma. Nuclei (red), conjonctive tissues (blue) and gene expression (white) are shown simultaneously. In superficial BCCs, only few cells express Delta-1 mRNAs in basal layer (A). The level of Notch-1 transcripts is very low in nodular BCC (B). Lu Fringe transcripts in deeply infiltrating BCC (C) are only detected at the margin of surgical excision (arrowhead; C). The expression of the three Fringe genes is restricted to small areas in basal layer in infiltrating BCC having a sclero-dermic differentiation (D-F). Scale bar, 100 μm; Ma, Manic; Lu, Lunatic; Ra, Radical.

Back to article page