Figure 2

Immunohistochemical detection of psoriasin in skin Pattern of psoriasin expression in pre-neoplastic and neoplastic skin lesions detected by immunohistochemistry (panels A,C,E,F) with corresponding areas from H&E stains (panels B,D,F,H). Psoriasin is moderately (A, right) or highly (C) expressed in carcinoma in-situ alone and carcinoma in-situ associated with invasive carcinoma (E, upper), and downregulated in invasive squamous carcinoma (E, lower). Psoriasin is absent in invasive basal cell carcinoma (G, upper) in comparison with adjacent positively staining normal hair follicles (G, lower right). Original magnification, 200×.