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Figure 1 | BMC Dermatology

Figure 1

From: Altered decorin expression of systemic sclerosis by UVA1 (340–400 nm) phototherapy: Immunohistochemical analysis of 3 cases

Figure 1

Histological evaluation of site-matched skin biopsy specimens before (A, C, E) and after (B, D, F) UVA1 phototherapy Biopsy specimens were taken from sclerotic skin lesions of the forearms of patients 1 (A, B), 2 (C, D), and 3 (E, F). Before UVA1 therapy, there are enlarged collagen bundles in the dermis. After UVA1 irradiation, histological analysis shows a loosening of collagen bundles, the appearance of small collagen fibers in the dermis and a decrease in the thickness of the dermal collagen. (Elastica van Gieson stain, original magnification × 200)

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