Figure 1

Schematics of transgenes The TGM1 promoter regions present in the six transgenes are depicted. Numbers indicate distances in kilobase pairs from the transcription start site, which is designated as 0. The promoter constructs all terminated at the 3' end at base pair +67 relative to the transcription start site. Arrowheads show the locations of AP1, CRE and CATAA (TATA-like) elements, with mutated sites indicated by an X. The position and direction of transcription of the human involucrin reporter (INV) are shown by an arrow.