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Figure 3 | BMC Dermatology

Figure 3

From: Psoriasis vulgaris flare during efalizumab therapy does not preclude future use: a case series

Figure 3

Immunohistochemistry of lesional skin biopsies during psoriatic flare of patient 1 and 2, showing similar features (magnification × 10). Haematoxylin and eosin (H&E) stain showing epidermal hyperplasia, elongation of rete ridges, dilatation of dermal papilla blood vessels, and mononuclear and neutrophil leukocyte infiltration. Some CD3 (BD) T cells infiltrate the dermis and epidermis, and these are mostly CD8+ (BD Pharmingen), although there are less T cells than during untreated psoriasis. Most of the epidermal T cells are CD103+ (Biodesign, Kennebunnk, ME). CD11c+ (BD Pharmingen) and iNOS+ (R&D Systems) cells are dramatically increased compared to non-lesional skin, and stain in a dendritic pattern.

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