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Table 2 Genotype and allele frequencies of TOLLIP polymorphisms in AD patients and healthy controls*.

From: Association of toll-interacting protein gene polymorphisms with atopic dermatitis

Polymorphism Genotype Allele AD Controls p-value
-526 C/G C/C   240 (76.9%) 181(84.6%)  
  C/G   65 (20.8%) 33 (15.4%)  
  G/G   7 (2.2%) 0 (0%)  
  n   312 214 0.08
   C 545 (87.3%) 395 (92.3%)  
   G 79 (12.7%) 33 (7.7%)  
   n 624 428 0.012
Intron1a A/A   265 (83.6 %) 199 (88.8%)  
  A/G   48 (15.1%) 25 (11.2%)  
  G/G   4 (1.3%) 0 (0%)  
  n   317 224 0.16
   A 578 (91.2%) 423 (94.4%)  
   G 56 (8.8%) 25 (5.6%)  
   n 634 448 0.045
Intron1b A/A   2 (0.6%) 3 (1.3%)  
  A/G   54 (17.3%) 39 (17.5%)  
  G/G   256 (82.1%) 181 (81.2%)  
  n   312 223 0.903
   A 58 (9.3%) 45 (10%)  
   G 566 (90.7%) 401 (90%)  
   n 624 446 0.66
Pro139Pro C/C   92 (30.4%) 64 (30.0%)  
  C/T   147 (48.5%) 113 (53.1%)  
  T/T   64 (21.1%) 36 (16.9%)  
  n   303 213 0.43
   C 331 (54.6%) 241 (56.6%)  
   T 275 (45.4%) 185 (43.4%)  
   n 606 426 0.52
Ala222Ser Ala/Ala   293 (94.5%) 198 (89.6%)  
  Ala/Ser   17 (5.5%) 22 (9.6%)  
  Ser/Ser   0 (0%) 1 (0.5%)  
  n   310 221 0.049
   Ala 603 (97.3%) 418 (94.6%)  
   Ser 17 (2.7%) 24 (5.4%)  
   n 620 442 0.02
3'UTR G/G   193 (61.5%) 133 (60.5%)  
  A/G   105 (33.4%) 76 (34.6%)  
  A/A   16 (5.1%) 11 (5.0%)  
  n   314 220 0.965
   G 491 (78.2%) 342 (77.7%)  
   A 137 (21.8%) 98 (22.3%)  
   n 628 440 0.86
  1. *According to the method of multiplicity correction for SNPs in LD that was introduced by Li & Ji [20], we considered p-values < 0.0102 as significant.