Table 2 Genotype and allele frequencies of TOLLIP polymorphisms in AD patients and healthy controls*.

-526 C/G

C/C

240 (76.9%)

181(84.6%)

C/G

65 (20.8%)

33 (15.4%)

G/G

7 (2.2%)

0 (0%)

n

312

214

0.08

C

545 (87.3%)

395 (92.3%)

G

79 (12.7%)

33 (7.7%)

n

624

428

0.012

Intron1a

A/A

265 (83.6 %)

199 (88.8%)

A/G

48 (15.1%)

25 (11.2%)

G/G

4 (1.3%)

0 (0%)

n

317

224

0.16

A

578 (91.2%)

423 (94.4%)

G

56 (8.8%)

25 (5.6%)

n

634

448

0.045

Intron1b

A/A

2 (0.6%)

3 (1.3%)

A/G

54 (17.3%)

39 (17.5%)

G/G

256 (82.1%)

181 (81.2%)

n

312

223

0.903

A

58 (9.3%)

45 (10%)

G

566 (90.7%)

401 (90%)

n

624

446

0.66

Pro139Pro

C/C

92 (30.4%)

64 (30.0%)

C/T

147 (48.5%)

113 (53.1%)

T/T

64 (21.1%)

36 (16.9%)

n

303

213

0.43

C

331 (54.6%)

241 (56.6%)

T

275 (45.4%)

185 (43.4%)

n

606

426

0.52

Ala222Ser

Ala/Ala

293 (94.5%)

198 (89.6%)

Ala/Ser

17 (5.5%)

22 (9.6%)

Ser/Ser

0 (0%)

1 (0.5%)

n

310

221

0.049

Ala

603 (97.3%)

418 (94.6%)

Ser

17 (2.7%)

24 (5.4%)

n

620

442

0.02

3'UTR

G/G

193 (61.5%)

133 (60.5%)

A/G

105 (33.4%)

76 (34.6%)

A/A

16 (5.1%)

11 (5.0%)

n

314

220

0.965

G

491 (78.2%)

342 (77.7%)

A

137 (21.8%)

98 (22.3%)

n

628

440

0.86