| Penciclovir cream (P) | Acyclovir cream (A) | Ratio (P/A) | Statistics | ||
---|---|---|---|---|---|---|
μg/cm2 | Mean | s.e.m | Mean | s.e.m |  | P value |
Strip 1 | 0.55 | 0.16 | 0.88 | 0.3 | 0.6 | 0.42 |
Strip 2 | 0.29 | 0.06 | 0.06 | 0.03 | 4.9 | 0.002 |
Pooled Strips | 0.32 | 0.12 | 0.07 | 0.04 | 4.5 | 0.07 |
Epidermis | 1.15 | 0.35 | 1.01 | 0.04 | 1.1 | 0.32 |
Dermis (residual stripped skin) | 0.10 | 0.04 | 0.07 | 0.04 | 1.4 | 0.63 |
Permeation through the skin (receptor phase) | 0.41 | 0.19 | 0.12 | 0.10 | 3.4 | 0.18 |
 | Penciclovir cream (P) | Acyclovir cream (A) | Ratio (P/A) | Statistics | ||
% applied dose | Mean | s.e.m | Mean | s.e.m | Â | P value |
Strip 1 | 1.15 | 0.41 | 0.30 | 0.11 | 3.8 | 0.06 |
Strip 2 | 0.61 | 0.16 | 0.02 | 0.01 | 29.1 | 0.002 |
Pooled Strips | 0.67 | 0.31 | 0.02 | 0.01 | 32.3 | 0.04 |
Epidermis | 2.4 | 0.9 | 0.3 | 0.1 | 7.0 | 0.3 |
Dermis (residual stripped skin) | 0.17 | 0.07 | 0.02 | 0.01 | 9.1 | 0.06 |
Permeation through the skin (receptor phase) | 0.68 | 0.33 | 0.04 | 0.03 | 16.7 | 0.06 |