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Table 1 Comparison of the amount of antiviral drug found in the various skin compartments.

From: Evaluation of the in vitro skin permeation of antiviral drugs from penciclovir 1% cream and acyclovir 5% cream used to treat herpes simplex virus infection

  Penciclovir cream (P) Acyclovir cream (A) Ratio (P/A) Statistics
μg/cm2 Mean s.e.m Mean s.e.m   P value
Strip 1 0.55 0.16 0.88 0.3 0.6 0.42
Strip 2 0.29 0.06 0.06 0.03 4.9 0.002
Pooled Strips 0.32 0.12 0.07 0.04 4.5 0.07
Epidermis 1.15 0.35 1.01 0.04 1.1 0.32
Dermis (residual stripped skin) 0.10 0.04 0.07 0.04 1.4 0.63
Permeation through the skin (receptor phase) 0.41 0.19 0.12 0.10 3.4 0.18
  Penciclovir cream (P) Acyclovir cream (A) Ratio
(P/A)
Statistics
% applied dose Mean s.e.m Mean s.e.m   P value
Strip 1 1.15 0.41 0.30 0.11 3.8 0.06
Strip 2 0.61 0.16 0.02 0.01 29.1 0.002
Pooled Strips 0.67 0.31 0.02 0.01 32.3 0.04
Epidermis 2.4 0.9 0.3 0.1 7.0 0.3
Dermis (residual stripped skin) 0.17 0.07 0.02 0.01 9.1 0.06
Permeation through the skin (receptor phase) 0.68 0.33 0.04 0.03 16.7 0.06
  1. Values represent mean from 11 replicates with standard error of the mean (s.e.m).
  2. In vitro human skin percutaneous absorption of penciclovir and acyclovir from creams as cumulative permeation and when adjusted to the applied dose.