Figure 1

Pedigrees of five families with familial keloids. Pedigrees for the five keloid families (D, F, H, K, and R) are shown. Notable features include the following: vertical transmission without consanguinity, male-to-male transmission, and approximately equal numbers of affected and unaffected individuals. Taken together, these findings support dominant or semidominant inheritance. Generations available for study are numbered with Roman numerals. Black symbols indicate keloids or keloids plus hypertrophic scar; gray symbols indicate hypertrophic scar only. Arrows denote probands. Question marks indicate individuals who were not available for study; this includes two individuals in the numbered generations. A dot identifies the three obligate carriers, assuming autosomal dominant inheritance.