Table 1 Upstream regulators significantly activated in UVB plus heat
From: Heat-mediated reduction of apoptosis in UVB-damaged keratinocytes in vitro and in human skin ex vivo
Upstream regulators | z score (p value) | Function | Reference | |
|---|---|---|---|---|
| Â | UVB | UVB plus Heat | Â | Â |
Pro-apoptotic signalling | ||||
TP53 | 3.25 (4×10 -6 ) | -2.04 (3.8×10 -14) | Cell arrest and/or apoptosis | |
CDKN1A | 2.60 (5×10 -9 ) |  | Inhibit cell proliferation and cell cycle progression | [53] |
Proliferation and Survival | ||||
NFkB (complex) | -2.87 (2×10 -4 ) | -1.34 (1×10 -2 ) | Cell survival | [54] |
ERK | -2.42 (7×10 -3) | -1.77 (1×10 -3) | Cell survival and proliferation | |
PI3K (complex) | -2.19 (3×10 -3) | -0.69 (1×10 -2) | Cell survival and proliferation | |
Akt | -1.99 (7×10 -2) |  | Cell survival and proliferation | |
Others | ||||
HSF-1 |  | 1.98 (2×10 -8) | Heat shock response regulator | |
SIRT1 |  | 2.16 (8×10 -4) | Cell proliferation and protection | [40] |
Hdac (Histone deacetylases) |  | 3.36 (2×10 -2) | p53 deacetylation and inhibition of nuclear translocation | |