Skip to main content
Fig. 1 | BMC Dermatology

Fig. 1

From: SIRT1 activation mediates heat-induced survival of UVB damaged Keratinocytes

Fig. 1

Exposure to repeated UVB plus heat significantly decreased acetylated p53 levels in keratinocytes. Representative immunohistochemical staining of ex vivo skin either untreated, or exposed to heat, UVB or UVB plus heat, for nuclear DNA (DAPI, blue), CPD (red) and (a) phosphorylated SIRT1 (SIRT1-p), (b) caspase (casp-3), (c) total p53 or (d) acetylated p53 (p53-a382). Inset images are an enlarged view of cells positive for CPD and SIRT1 (red arrows), CPD and Casp-3 (orange arrows), CPD and p53 (green arrows) or CPD and p53-a382 (blue arrows). Broken lines denote the epidermal/dermal border. All images are at 400X magnification

Back to article page