Table 1 Effect of UVB and/or heat exposure in keratinocytes of the ex vivo skin models or NHEK in vitro
From: SIRT1 activation mediates heat-induced survival of UVB damaged Keratinocytes
Percentage Mean ± S.D. | ||||
|---|---|---|---|---|
| Â | Untreated | Heat | UVB | UVB plus Heat |
Skin | ||||
 DNA Damaged Cells (%) | 0 ± 0 | 5 ± 3 | 84 ± 7 | 79 ± 3 |
 Apoptotic Cells (%) | 0 ± 0 | 14 ± 1 | 37 ± 3 | 15 ± 4*** |
 SIRT1-p+/CPD+ (%) | 0 ± 0 | 32 ± 2 | 0 ± 0 | 50 ± 3 |
 Apoptotic Cells (%) | 0 ± 0 | 14 ± 1 | 37 ± 3 | 15 ± 4*** |
 p53+/CPD+ (%) | 0 ± 0 | 0 ± 0 | 76 ± 3 | 69 ± 3 |
 p53-ace382+/CPD+ (%) | 0 ± 0 | 0 ± 0 | 79 ± 6 | 40 ± 2** |
NHEK | ||||
 DNA Damaged Cells (%) | 0 ± 0 | 2 ± 1 | 91 ± 8 | 87 ± 3 |
 Apoptotic Cells (%) | 2 ± 1 | 3 ± 1 | 25 ± 3 | 7 ± 4 |
 SIRT1-p+/CPD+ (%) | 1 ± 1 | 34 ± 5 | 0 ± 0 | 55 ± 3** |
 p53+/CPD+ (%) | 0 ± 0 | 0 ± 0 | 84 ± 3 | 79 ± 2 |
 p53-ace382+/CPD+ (%) | 0 ± 0 | 0 ± 0 | 75 ± 4 | 28 ± 7** |