TY - JOUR AU - Albino, A. P. AU - Nanus, D. M. AU - Mentle, I. R. AU - Cordon-Cardo, C. AU - McNutt, N. S. AU - Bressler, J. PY - 1989 DA - 1989// TI - Analysis of ras oncogenes in malignant melanoma and precursor lesions: correlation of point mutations with differentiation phenotype JO - Oncogene VL - 4 ID - Albino1989 ER - TY - JOUR AU - Davies, H. AU - Bignell, G. R. AU - Cox, C. AU - Stephens, P. AU - Edkins, S. AU - Clegg, S. PY - 2002 DA - 2002// TI - Mutations of the BRAF gene in human cancer JO - Nature VL - 417 UR - https://doi.org/10.1038/nature00766 DO - 10.1038/nature00766 ID - Davies2002 ER - TY - JOUR AU - Curtin, J. A. AU - Fridlyand, J. AU - Kageshita, T. AU - Patel, H. N. AU - Busam, K. J. AU - Kutzner, H. PY - 2005 DA - 2005// TI - Distinct sets of genetic alterations in melanoma JO - N Engl J Med VL - 353 UR - https://doi.org/10.1056/NEJMoa050092 DO - 10.1056/NEJMoa050092 ID - Curtin2005 ER - TY - JOUR AU - Tsao, H. AU - Chin, L. AU - Garraway, L. A. AU - Fisher, D. E. PY - 2012 DA - 2012// TI - Melanoma: from mutations to medicine JO - Genes Dev VL - 26 UR - https://doi.org/10.1101/gad.191999.112 DO - 10.1101/gad.191999.112 ID - Tsao2012 ER - TY - STD TI - Cancer Genome Atlas Network. Genomic Classification of Cutaneous Melanoma. 2015. Cell 2015, 161:1681–1696. ID - ref5 ER - TY - JOUR AU - Long, G. V. AU - Menzies, A. M. AU - Nagrial, A. M. AU - Haydu, L. E. AU - Hamilton, A. L. AU - Mann, G. J. PY - 2011 DA - 2011// TI - Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma JO - J Clin Oncol VL - 29 UR - https://doi.org/10.1200/JCO.2010.32.4327 DO - 10.1200/JCO.2010.32.4327 ID - Long2011 ER - TY - JOUR AU - Greaves, W. O. AU - Verma, S. AU - Patel, K. P. AU - Davies, M. A. AU - Barkoh, B. A. AU - Galbincea, J. M. PY - 2013 DA - 2013// TI - Frequency and spectrum of BRAF mutations in a retrospective, single-institution study of 1112 cases of melanoma JO - J Mol Diagn VL - 15 UR - https://doi.org/10.1016/j.jmoldx.2012.10.002 DO - 10.1016/j.jmoldx.2012.10.002 ID - Greaves2013 ER - TY - JOUR AU - Omholt, K. AU - Platz, A. AU - Kanter, L. AU - Ringborg, U. AU - Hansson, J. PY - 2003 DA - 2003// TI - NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression JO - Clin Cancer Res VL - 9 ID - Omholt2003 ER - TY - JOUR AU - Akslen, L. A. AU - Angelini, S. AU - Straume, O. AU - Bachmann, I. M. AU - Molven, A. AU - Hemminki, K. PY - 2005 DA - 2005// TI - BRAF and NRAS mutations are frequent in nodular melanoma but are not associated with tumor cell proliferation or patient survival JO - J Invest Dermatol VL - 125 UR - https://doi.org/10.1111/j.0022-202X.2005.23788.x DO - 10.1111/j.0022-202X.2005.23788.x ID - Akslen2005 ER - TY - JOUR AU - Thumar, J. AU - Shahbazian, D. AU - Aziz, S. A. AU - Jilaveanu, L. B. AU - Kluger, H. M. PY - 2014 DA - 2014// TI - MEK targeting in N-RAS mutated metastatic melanoma JO - Mol Cancer VL - 13 UR - https://doi.org/10.1186/1476-4598-13-45 DO - 10.1186/1476-4598-13-45 ID - Thumar2014 ER - TY - JOUR AU - Devitt, B. AU - Liu, W. AU - Salemi, R. AU - Wolfe, R. AU - Kelly, J. AU - Tzen, C. Y. PY - 2011 DA - 2011// TI - Clinical outcome and pathological features associated with NRAS mutation in cutaneous melanoma JO - Pigment Cell Melanoma Res VL - 24 UR - https://doi.org/10.1111/j.1755-148X.2011.00873.x DO - 10.1111/j.1755-148X.2011.00873.x ID - Devitt2011 ER - TY - JOUR AU - Ellerhorst, J. A. AU - Greene, V. R. AU - Ekmekcioglu, S. AU - Warneke, C. L. AU - Johnson, M. M. AU - Cooke, C. P. PY - 2011 DA - 2011// TI - Clinical correlates of NRAS and BRAF mutations in primary human melanoma JO - Clin Cancer Res VL - 17 UR - https://doi.org/10.1158/1078-0432.CCR-10-2276 DO - 10.1158/1078-0432.CCR-10-2276 ID - Ellerhorst2011 ER - TY - JOUR AU - Jakob, J. A. AU - Bassett, R. L. AU - Ng, C. S. AU - Curry, J. L. AU - Joseph, R. W. AU - Alvarado, G. C. PY - 2012 DA - 2012// TI - NRAS mutation status is an independent prognostic factor in metastatic melanoma JO - Cancer VL - 118 UR - https://doi.org/10.1002/cncr.26724 DO - 10.1002/cncr.26724 ID - Jakob2012 ER - TY - JOUR AU - Chapman, P. B. AU - Hauschild, A. AU - Robert, C. AU - Haanen, J. B. AU - Ascierto, P. AU - Larkin, J. PY - 2011 DA - 2011// TI - BRIM-3 study group. Improved survival with vemurafenib in melanoma with BRAF V600E mutation JO - N Engl J Med VL - 364 UR - https://doi.org/10.1056/NEJMoa1103782 DO - 10.1056/NEJMoa1103782 ID - Chapman2011 ER - TY - JOUR AU - Hauschild, A. AU - Grob, J. J. AU - Demidov, L. V. AU - Jouary, T. AU - Gutzmer, R. AU - Millward, M. PY - 2012 DA - 2012// TI - Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial JO - Lancet VL - 380 UR - https://doi.org/10.1016/S0140-6736(12)60868-X DO - 10.1016/S0140-6736(12)60868-X ID - Hauschild2012 ER - TY - JOUR AU - Long, G. V. AU - Stroyakovskiy, D. AU - Gogas, H. AU - Levchenko, E. AU - Braud, F. AU - Larkin, J. PY - 2014 DA - 2014// TI - Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma JO - N Engl J Med VL - 371 UR - https://doi.org/10.1056/NEJMoa1406037 DO - 10.1056/NEJMoa1406037 ID - Long2014 ER - TY - JOUR AU - Long, G. V. AU - Stroyakovskiy, D. AU - Gogas, H. AU - Levchenko, E. AU - Braud, F. AU - Larkin, J. PY - 2015 DA - 2015// TI - Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: a multicentre, double-blind, phase 3 randomised controlled trial JO - Lancet VL - 386 UR - https://doi.org/10.1016/S0140-6736(15)60898-4 DO - 10.1016/S0140-6736(15)60898-4 ID - Long2015 ER - TY - JOUR AU - Robert, C. AU - Karaszewska, B. AU - Schachter, J. AU - Rutkowski, P. AU - Mackiewicz, A. AU - Stroiakovski, D. PY - 2015 DA - 2015// TI - Improved overall survival in melanoma with combined dabrafenib and trametinib JO - N Engl J Med VL - 372 UR - https://doi.org/10.1056/NEJMoa1412690 DO - 10.1056/NEJMoa1412690 ID - Robert2015 ER - TY - STD TI - Dummer R, Schadendorf D, Ascierto PA, Arance Fernández AM, Dutriaux C, Maio M,et al. Results of NEMO: A phase III trial of binimetinib (BINI) vs dacarbazine (DTIC) in NRAS-mutant cutaneous melanoma. J Clin Oncol 2016, ASCO Meeting Abstracts 34:9500. ID - ref19 ER - TY - JOUR AU - Hélias-Rodzewicz, Z. AU - Funck-Brentano, E. AU - Baudoux, L. AU - Jung, C. K. AU - Zimmermann, U. AU - Marin, C. PY - 2015 DA - 2015// TI - Variations of BRAF mutant allele percentage in melanomas JO - BMC Cancer VL - 15 UR - https://doi.org/10.1186/s12885-015-1515-3 DO - 10.1186/s12885-015-1515-3 ID - Hélias-Rodzewicz2015 ER - TY - JOUR AU - Lebbé, C. AU - How-Kit, A. AU - Battistella, M. AU - Sadoux, A. AU - Podgorniak, M. P. AU - Sidina, I. PY - 2014 DA - 2014// TI - BRAF(V600) mutation levels predict response to vemurafenib in metastatic melanoma JO - Melanoma Res VL - 24 UR - https://doi.org/10.1097/CMR.0000000000000088 DO - 10.1097/CMR.0000000000000088 ID - Lebbé2014 ER - TY - JOUR AU - Colomba, E. AU - Hélias-Rodzewicz, Z. AU - Deimling, A. AU - Marin, C. AU - Terrones, N. AU - Pechaud, D. PY - 2013 DA - 2013// TI - Detection of BRAF p.V600E mutations in melanomas: comparison of four methods argues for sequential use of immunohistochemistry and pyrosequencing JO - J Mol Diagn VL - 15 UR - https://doi.org/10.1016/j.jmoldx.2012.09.001 DO - 10.1016/j.jmoldx.2012.09.001 ID - Colomba2013 ER - TY - JOUR AU - Moreau, S. AU - Saiag, P. AU - Aegerter, P. AU - Bosset, D. AU - Longvert, C. AU - Hélias-Rodzewicz, Z. PY - 2012 DA - 2012// TI - Prognostic value of BRAFV600 mutations inmelanoma patients after resection of metastatic lymph nodes JO - Ann SurgOncol VL - 2012 ID - Moreau2012 ER - TY - JOUR AU - Balschun, K. AU - Haag, J. AU - Wenke, A. K. AU - Schönfels, W. AU - Schwarz, N. T. AU - Röcken, C. PY - 2011 DA - 2011// TI - KRAS, NRAS, PIK3CA exon 20, and BRAF genotypes in synchronous and metachronous primary colorectal cancers diagnostic and therapeutic implications JO - J Mol Diagn VL - 2011 UR - https://doi.org/10.1016/j.jmoldx.2011.03.002 DO - 10.1016/j.jmoldx.2011.03.002 ID - Balschun2011 ER - TY - JOUR AU - Lourenço, N. AU - Hélias-Rodzewicz, Z. AU - Bachet, J. B. AU - Brahimi-Adouane, S. AU - Jardin, F. PY - 2014 DA - 2014// TI - Tran van Nhieu J, Peschaud F, Martin E, Beauchet A, Chibon F JO - Emile JF Copy-neutral loss of heterozygosity and chromosome gains and losses are frequent in gastrointestinal stromal tumors Mol Cancer VL - 13 ID - Lourenço2014 ER - TY - STD TI - Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO,et al Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal 2013, 6:pl1. ID - ref26 ER - TY - JOUR AU - Ilie, M. AU - Long-Mira, E. AU - Funck-Brentano, E. AU - Lassalle, S. AU - Butori, C. AU - Lespinet-Fabre, V. PY - 2015 DA - 2015// TI - Immunohistochemistry as a potential tool for routine detection of the NRAS Q61R mutation in patients with metastatic melanoma JO - J Am Acad Dermatol VL - 72 UR - https://doi.org/10.1016/j.jaad.2015.01.012 DO - 10.1016/j.jaad.2015.01.012 ID - Ilie2015 ER - TY - JOUR AU - Funck-Brentano, E. AU - Hélias-Rodzewicz, Z. AU - Longvert, C. AU - Mokhtari, K. AU - Saiag, P. AU - Emile, J. F. PY - 2016 DA - 2016// TI - Increase in NRAS mutant allele percentage during metastatic melanoma progression JO - Exp Dermatol VL - 25 UR - https://doi.org/10.1111/exd.13001 DO - 10.1111/exd.13001 ID - Funck-Brentano2016 ER - TY - JOUR AU - Soh, J. AU - Okumura, N. AU - Lockwood, W. W. AU - Yamamoto, H. AU - Shigematsu, H. AU - Zhang, W. PY - 2009 DA - 2009// TI - Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells JO - PLoS One VL - 4 UR - https://doi.org/10.1371/journal.pone.0007464 DO - 10.1371/journal.pone.0007464 ID - Soh2009 ER - TY - JOUR AU - Xu, J. AU - Haigis, K. M. AU - Firestone, A. J. AU - McNerney, M. E. AU - Li, Q. AU - Davis, E. PY - 2013 DA - 2013// TI - Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation JO - Cancer Discov VL - 3 UR - https://doi.org/10.1158/2159-8290.CD-13-0096 DO - 10.1158/2159-8290.CD-13-0096 ID - Xu2013 ER - TY - JOUR AU - Chen, X. AU - Mitsutake, N. AU - LaPerle, K. AU - Akeno, N. AU - Zanzonico, P. AU - Longo, V. A. PY - 2009 DA - 2009// TI - Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene JO - Proc Natl Acad Sci U S A VL - 106 UR - https://doi.org/10.1073/pnas.0900343106 DO - 10.1073/pnas.0900343106 ID - Chen2009 ER - TY - JOUR AU - Chen, X. AU - Makarewicz, J. M. AU - Knauf, J. A. AU - Johnson, L. K. AU - Fagin, J. A. PY - 2014 DA - 2014// TI - Transformation by Hras(G12V) is consistently associated with mutant allele copy gains and is reversed by farnesyl transferase inhibition JO - Oncogene VL - 33 UR - https://doi.org/10.1038/onc.2013.489 DO - 10.1038/onc.2013.489 ID - Chen2014 ER - TY - JOUR AU - Gast, A. AU - Scherer, D. AU - Chen, B. AU - Bloethner, S. AU - Melchert, S. AU - Sucker, A. PY - 2010 DA - 2010// TI - Somatic alterations in the melanoma genome: a high-resolution array-based comparative genomic hybridization study JO - Genes Chromosomes Cancer VL - 49 UR - https://doi.org/10.1002/gcc.20785 DO - 10.1002/gcc.20785 ID - Gast2010 ER - TY - JOUR AU - Dubruc, E. AU - Balme, B. AU - Dijoud, F. AU - Disant, F. AU - Thomas, L. AU - Wang, Q. PY - 2014 DA - 2014// TI - Mutated and amplified NRAS in a subset of cutaneous melanocytic lesions with dermal spitzoid morphology: report of two pediatric cases located on the ear JO - J Cutan Pathol VL - 2014 UR - https://doi.org/10.1111/cup.12389 DO - 10.1111/cup.12389 ID - Dubruc2014 ER - TY - JOUR AU - Stark, M. AU - Hayward, N. PY - 2007 DA - 2007// TI - Genome-wide loss of heterozygosity and copy number analysis in melanoma using high-density single-nucleotide polymorphism arrays JO - Cancer Res VL - 67 UR - https://doi.org/10.1158/0008-5472.CAN-06-4152 DO - 10.1158/0008-5472.CAN-06-4152 ID - Stark2007 ER - TY - JOUR AU - Modrek, B. AU - Ge, L. AU - Pandita, A. AU - Lin, E. AU - Mohan, S. AU - Yue, P. PY - 2009 DA - 2009// TI - Oncogenic activating mutations are associated with local copy gain JO - Mol Cancer Res VL - 2009 UR - https://doi.org/10.1158/1541-7786.MCR-08-0532 DO - 10.1158/1541-7786.MCR-08-0532 ID - Modrek2009 ER - TY - JOUR AU - Rumi, E. AU - Pietra, D. AU - Guglielmelli, P. AU - Bordoni, R. AU - Casetti, I. AU - Milanesi, C. PY - 2013 DA - 2013// TI - Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative. Acquired copy-neutral loss of heterozygosity of chromosome 1p as a molecular event associated with marrow fibrosis in MPL-mutated myeloproliferative neoplasms JO - Blood VL - 121 UR - https://doi.org/10.1182/blood-2013-02-486050 DO - 10.1182/blood-2013-02-486050 ID - Rumi2013 ER - TY - JOUR AU - Dunbar, A. J. AU - Gondek, L. P. AU - O'Keefe, C. L. AU - Makishima, H. AU - Rataul, M. S. AU - Szpurka, H. PY - 2008 DA - 2008// TI - 250K single nucleotide polymorphism array karyotyping identifies acquired uniparental disomy and homozygous mutations, including novel missense substitutions of c-Cbl, in myeloid malignancies JO - Cancer Res VL - 2008 UR - https://doi.org/10.1158/0008-5472.CAN-08-2754 DO - 10.1158/0008-5472.CAN-08-2754 ID - Dunbar2008 ER -