Table 3 Comparison of pathways enriched in eSkIN and DAVID analysis
From: Elucidating mechanistic insights into drug action for atopic dermatitis: a systems biology approach
S.No. | Important pathways enriched in eSkIN | Related processes/pathways enriched in BM samples | Related processes/pathways enriched in PC samples | ||
|---|---|---|---|---|---|
GO_BP_FAT | KEGG | GO_BP_FAT | KEGG | ||
1. | Keratinocyte differentiation, Cornification, Basal layer formation | keratinocyte differentiation, skin development, keratinization, skin epidermis development | – | epidermis development, skin development, keratinocyte differentiation, epidermal cell differentiation, keratinization | – |
2. | Inflammation | inflammatory response, regulation of inflammatory response, T-cell activation | TNF signaling pathway, NF-κB signaling pathway, Inflammatory bowel disease | – | – |
3. | Immune response | Immune response, defense response, Innate immune response | – | Immune response, defense response, Innate immune response | – |
4. | Chemokine signaling | Chemokine mediated signaling pathway and chemokine production | Chemokine signaling pathway, Cytokine-cytokine receptor interaction | – | – |
5. | DNA Damage and Repair | DNA integrity checkpoint | – | – | – |
6. | Cell Adhesion, Cell Migration | Cell adhesion, leukocyte cell-cell adhesion, cell migration, regulation of cell migration, leukocyte migration | Cell adhesion molecules (CAMs) | Cell migration, leukocyte migration | – |