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Table 1 PGA Confirmatory Factor Analysis

From: A multi-item Physician Global Assessment scale to assess psoriasis disease severity: validation based on four phase III tofacitinib studies

Study CFIa (constrained paths) CFIa (unconstrained paths)   Difference between path coefficients (constrained vs unconstrained), %
Erythema Induration Scaling
OPT Pivotal 1 0.995 0.996 Baseline −18.1 16.7 4.2
Week 16 0.5 1.9 −1.6
OPT Pivotal 2 0.983 0.995 Baseline −9.5 18.7* −5.0
Week 16 −5.5* 5.0 −1.8
OPT Compare 0.988 0.997 Baseline −16.8* 16.6* 0.6
Week 12 −3.2 5.5 −3.9
OPT Retreatment 0.981 0.994 Baseline −34.3* 38.9* 0.8
Week 24 −6.0 2.8* 0.9
  1. *p < 0.05 vs zero
  2. aBentler’s Comparative Fit Index (CFI)
  3. PGA Physician Global Assessment