Skip to main content

Table 5 Comparisons of mean differences in ADCT total score by PGAD and DLQI known groups

From: Validation of the Atopic Dermatitis Control Tool (ADCT©) using a longitudinal survey of biologic-treated patients with atopic dermatitis

Assessment period Subgroups N ADCT total score, mean (SD) Mean ADCT total score differences (95% CI) p-value Cohen’s d
Patient Global Assessment of Disease (PGAD)
 Baseline Excellent 3 8.67 (7.64) – – – –
Very good 31 9.90 (5.88) Excellent vs very good −1.24 (−8.64, 6.16) 0.736 −0.17a
Good 240 12.85 (5.44) Very good vs good −2.95 (−5.01, − 0.89) 0.005 −0.52
Fair 496 15.79 (4.64) Good vs fair −2.94 (−3.70, −2.18) < 0.001 −0.58
Poor 240 19.83 (3.97) Fair vs poor −4.03 (−4.72, −3.35) < 0.001 −0.93
 Month 1 Excellent 71 1.63 (2.02) – – – –
Very good 177 3.85 (2.72) Excellent vs very good −2.22 (−2.92, −1.52) < 0.001 −0.93
Good 175 7.27 (4.00) Very good vs good −3.42 (−4.14, −2.70) < 0.001 −1.00
Fair 101 11.40 (4.63) Good vs fair −4.12 (−5.17, −3.08) < 0.001 −0.95
Poor 14 16.29 (4.05) Fair vs poor −4.89 (−7.47, −2.31) < 0.001 −1.12
 Month 3 Excellent 89 1.46 (2.09) – – – –
Very good 126 3.64 (2.53) Excellent vs very good −2.18 (−2.83, −1.54) < 0.001 −0.94
Good 98 7.58 (4.59) Very good vs good −3.94 (−4.89, −2.99) < 0.001 −1.06
Fair 52 11.27 (4.63) Good vs fair −3.69 (−5.25, −2.13) < 0.001 −0.80
Poor 7 19.57 (2.37) Fair vs poor −8.30 (−11.89, −4.72) < 0.001 −2.26
 Month 6 Excellent 57 1.58 (1.93) – – – –
Very good 71 3.23 (2.13) Excellent vs very good −1.65 (−2.36, −0.93) < 0.001 −0.81
Good 57 6.81 (3.99) Very good vs good −3.58 (−4.67, −2.49) < 0.001 −1.12
Fair 16 12.75 (5.41) Good vs fair −5.94 (−8.39, −3.50) < 0.001 −1.25
Poor 5 17.40 (3.36) Fair vs poor −4.65 (−10.06, 0.76) 0.088 −0.94a
Dermatology Life Quality Index (DLQI) bands
 Baseline No effect 0 – – – – –
Small 21 13.67 (4.86) – – – –
Moderate 351 12.74 (5.26) Small vs moderate 0.92 (−1.39, 3.24) 0.433 0.18
Very large 511 16.85 (4.66) Moderate vs very large −4.11 (−4.78, −3.44) < 0.001 −0.83
Extremely large 127 20.79 (3.48) Very large vs extremely large −3.94 (−4.80, −3.07) < 0.001 −0.96
 Month 1 No effect 137 2.05 (1.82)     
Small 214 5.25 (3.08) No vs small −3.20 (−3.77, −2.63) < 0.001 −1.26
Moderate 107 8.66 (3.75) Small vs moderate −3.41 (−4.18, −2.64) < 0.001 −0.99
Very large 67 13.43 (4.39) Moderate vs very large −4.77 (−6.00, −3.54) < 0.001 −1.17
Extremely large 13 16.77 (3.49) Very large vs extremely large −3.34 (−5.91, −0.76) 0.012 −0.84
 Month 3 No effect 136 1.75 (1.78) – – – –
Small 131 4.83 (2.83) No vs small −3.08 (−3.65, −2.52) < 0.001 −1.31
Moderate 65 8.71 (3.78) Small vs moderate −3.88 (−4.82, −2.93) < 0.001 −1.16
Very large 30 14.00 (4.18) Moderate vs very large −5.29 (−7.00, −3.58) < 0.001 −1.33
Extremely large 10 19.80 (2.35) Very large vs extremely large −5.80 (−8.63, −2.97) < 0.001 −1.64a
 Month 6 No effect 95 1.91 (1.79) – – – –
Small 64 4.61 (3.24) No vs small −2.70 (−3.50, −1.91) < 0.001 −1.03
Moderate 27 8.74 (3.39) Small vs moderate −4.13 (−5.63, −2.63) < 0.001 −1.25
Very large 18 14.06 (4.52) Moderate vs very large −5.31 (−7.69, −2.94) < 0.001 −1.28a
Extremely large 2 16.50 (7.78) Very large vs extremely large −2.44 (−9.89, 5.01) 0.499 −0.35a
  1. aCohen’s d was corrected for small sample sizes. The correction factor was (N–3)/(N–2.25) x sqrt (1–2/N)
  2. ADCT Atopic Dermatitis Control Tool, CI Confidence interval, SD Standard deviation
Back to article page

BMC Dermatology

ISSN: 1471-5945

Contact us