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Table 1 Characteristics of patients with severe atopic dermatitis at start of treatment

From: Weight gain in patients with severe atopic dermatitis treated with dupilumab: a cohort study

 

Methotrexate (n = 8)

Dupilumab (n = 12)

p value

Mean

95% CI

Mean

95% CI

Age (years)

56.4

46.0–66.7

46.9

39.6–54.2

0.189

Male sex (%)

62.5

24.5–91.5

83.3

51.6–97.9

0.304

EASI

15.3

8.9–21.7

27.6

18.7–36.5

0.045*

POEM

18.0

11.2–24.8

18.6

13.5–23.7

0.816

VAS

6.0

3.5–8.4

5.9

4.0–7.8

0.817

DLQI

17

12.3–21.7

9.4

4.5–14.3

0.025*

MADRS

11.7

6.3–17.1

12.8

3.8–21.9

0.421

Weight (kg)

75.3

64.7–85.8

84.8

73.4–96.1

0.142

BMI (kg/m2)

24.7

19.9–36.1

27.3

24.0–28.4

0.123

  1. Abbreviations: CI Confidence interval, EASI Eczema area severity score, POEM Patient-oriented eczema measure, VAS Visual analogue scale, DLQI Dermatology life quality index, MADRS Montgomery-Åsberg depression rating scale, BMI Body Mass Index
  2. Significant differences marked with *. P values calculated using two-sample Wilcoxon-Mann-Whitney rank-sum tests