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Table 1 Top findings for hair follicle eQTLs

From: Mapping of cis-acting expression quantitative trait loci in human scalp hair follicles

Gene

# eQTLs

Best eSNP

Chr

Position

A1

A2

P

FDR

Effect

Top 20 independent eQTLs (discovery sample)

 IPO8

183

rs7326

12

30,782,301

G

A

5.17E-31

1.56E-24

−0.6840

 ATP5MD

95

rs2271751

10

105,175,131

C

T

5.80E-26

3.21E-20

1.1004

 C17ORF97

35

rs11150881

17

259,304

G

A

2.18E-25

1.18E-19

0.6600

 TIMM10

9

rs3851117

11

57,237,113

A

G

4.60E-25

2.11E-19

−0.8391

 KCTD10

211

rs4766601

12

109,890,080

C

G

9.89E-25

4.49E-19

0.5773

 C5ORF35/SETD9

50

rs2591963

5

56,237,135

A

T

1.50E-24

6.43E-19

−0.6930

 NDUFS5

45

rs374279960

1

39,484,742

G

T

2.36E-24

1.01E-18

−0.2496

 LOC339804

267

rs3213944

2

61,372,298

G

C

8.36E-24

2.50E-18

0.4471

 FMO1

45

rs6674596

1

171,235,088

T

A

1.04E-23

3.07E-18

1.3913

 PARP12

32

rs2286197

7

139,726,467

G

A

1.19E-23

3.46E-18

0.3402

 SH3YL1

50

rs62114506

2

242,793

C

G

1.30E-23

3.78E-18

−0.5886

 PEX6

57

rs3805946

6

42,955,749

C

T

1.47E-23

4.11E-18

0.5651

 FN3KRP

109

rs2249888

17

80,675,738

G

A

1.54E-23

4.11E-18

0.3341

 BCR

44

rs131703

22

23,652,201

G

A

6.23E-23

1.36E-17

0.4445

 PSMG1

295

rs35064900

21

40,555,492

G

A

7.92E-23

1.55E-17

−0.3917

 RPS26L

47

rs773114

12

56,379,060

T

A

1.14E-22

2.12E-17

0.4386

 GOLGB1

24

rs9968051

3

121,384,081

G

C

3.20E-22

5.56E-17

−0.6104

 ERP27

182

rs12312821

12

15,077,527

T

A

4.48E-22

7.63E-17

−0.6385

 SLC47A2

51

rs12451902

17

19,619,063

G

A

1.02E-21

1.65E-16

0.6855

 ABHD12

517

rs2258728

20

25,276,343

A

G

1.91E-21

2.88E-16

0.2737

Top 10 eQTLs in frontal scalp (replication sample)

 TDRD6

14

rs552053483

6

46,870,456

C

A

5.32E-12

4.08E-06

0.4313

 CXCL1

32

rs191105830

4

75,248,687

G

A

3.07E-09

7.16E-04

0.4703

 ZXDC

12

rs552704609

3

126,534,497

A

C

4.70E-08

0.00871

0.3945

 COA4

2

rs34214542

11

74,207,014

G

T

7.82E-08

0.01141

0.3317

 DLG2

25

rs141374880

11

83,245,973

A

G

8.60E-08

0.01141

0.4126

 TADA2A

3

rs74398459

17

36,095,246

G

T

1.17E-07

0.01446

0.3338

 C17orf67

2

rs187188078

17

55,455,184

T

C

1.46E-07

0.01761

0.6551

 FAM220A

16

rs188128204

7

6,373,651

A

G

2.11E-07

0.02083

0.4342

 ARMC6

5

rs150042710

19

18,518,809

T

C

2.40E-07

0.02262

0.6410

 NUP153

10

rs115808997

6

17,571,313

T

C

4.54E-07

0.03605

−0.4850

Top 10 eQTLs in occipital scalp (replication sample)

 TELO2

17

rs561125041

16

1,464,247

T

C

8.51E-10

3.00E-04

1.2115

 LPHN1

17

rs147147550

19

14,373,177

T

C

9.90E-10

3.00E-04

0.6231

 ENTHD2

5

rs117860115

17

78,992,225

T

C

4.10E-09

0.00121

0.1629

 GCSAM

2

rs139726887

3

112,327,159

T

C

3.41E-08

0.00496

0.3622

 CCL2

11

rs72825069

17

32,600,928

T

C

6.38E-08

0.00678

1.7221

 RUFY3

3

rs115702490

4

72,452,170

T

C

1.24E-07

0.01296

0.4149

 GGPS1

6

rs115335216

1

236,067,212

T

G

2.13E-07

0.01422

0.2215

 MTF1

10

rs3935450

1

37,656,324

G

T

2.65E-07

0.01763

−0.2218

 CXADR

4

rs55707799

21

18,849,240

C

T

3.47E-07

0.02132

−0.4272

 KRT37

1

rs35490951

17

40,250,939

C

A

3.65E-07

0.02132

1.8106

  1. The top 20 hair follicle eQTLs obtained from human occipital scalp in the discovery sample and the top 10 hair follicle eQTLs obtained from frontal and occipital scalp in the replication sample are shown
  2. eQTLs expression quantitative trait loci, eSNP SNP with eQTL effect, Chr chromosome, A1 effect allele, A2 other allele, P p-value, FDR false discovery rate
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BMC Dermatology

ISSN: 1471-5945

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