Figure 3
From: Toll-like receptor 2 activation and comedogenesis: implications for the pathogenesis of acne
TLR activation promotes hypercornification in isolated human sebaceous glands maintained ex vivo . A) Histological sections of freshly-isolated and IL-1α treated sebaceous glands are shown, along with an example of a comedone in situ. B) Morphology representative of 3 experiments showing sebaceous glands treated with vehicle only (control), TLR2 (LTA and PGN) or TLR4 agonists (LPS), or TLR agonists pre-incubated with a blocking antibody (block). All images are shown at 10 × original magnification.