Response/Parameter | Week 12 | Week 24 | ||
---|---|---|---|---|
QW/QW n = 86 | BIW/QW n = 84 | QW/QW n = 86 | BIW/QW n = 84 | |
PASI 50, % of patients (95 % CI) | 72.1 (61.4, 81.2) | 91.7* (83.6, 96.6) | 80.2 (70.2, 88.0) | 90.5 (82.1, 95.8) |
PASI 75, % of patients (95 % CI) | 39.5 (29.2, 50.7) | 66.7* (55.5, 76.6) | 62.8 (51.7, 73.0) | 83.3* (73.6, 90.6) |
PASI 90, % of patients (95 % CI) | 14.0 (7.4, 23.1) | 32.1* (22.4, 43.2) | 37.2 (27.0, 48.3) | 56.0* (44.7, 66.8) |
Adjusted mean change from baseline in total PGA score, mean (SEM) | −1.5† (0.1) | −2.0*† (0.1) | −1.9† (0.1) | −2.2*† (0.1) |
PGA clear/almost clear, % of patients (95 % CI) | 36.0† (26.0, 47.1) | 56.0*† (44.7, 66.8) | 57.0† (45.8, 67.6) | 71.4† (60.5, 80.8) |
Adjusted mean % change in affected body surface area, mean (SEM) | −14.6† (1.7) | −23.2*† (1.7) | −21.7† (1.5) | 29.6*† (1.5) |