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Figure 1 | BMC Dermatology

Figure 1

From: Measurement of matrix metalloproteinase 9-mediated Collagen type III degradation fragment as a marker of skin fibrosis

Figure 1

Skin section from a control, PBS-treated mouse at 8 weeks of treatment. (A). Skin section from a bleomycin-treated mouse at 8 weeks of treatment (B). The mean skin thickness increase between control PBS-(n = 7/time point) and bleomycin- (n = 13/time point) treated mice at 2 weeks was 12.43 vs. 15.4 arbitrary units respectively, P = 0.0029); at 4 weeks, 12.7 vs. 18.6, P = 0.0004; 6 weeks, 13.1 vs. 19.4, P < 0.0001; and at 8 weeks, 12.5 vs. 21.8, P < 0.0001 (C). Overall mean skin thickness increased between control PBS treated- (n = 28) and bleomycin- (n = 52) treated mice for the 8-week duration of the study (11.9 vs. 19.4 arbitrary units respectively, P < 0.0001). Skin thickness was calculated by Visiopharm software as an overall number per skin section, rather than by estimating density from pictures.

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BMC Dermatology

ISSN: 1471-5945

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