Case report and summary of literature: giant perineal keloids treated with post-excisional radiotherapy

Jones, Kristin; Fuller, Clifton D; Luh, Join Y; Childs, Craig C; Miller, Alexander R; Tolcher, Anthony W; Herman, Terence S; Thomas, Charles R

doi:10.1186/1471-5945-6-7

BMC Dermatology

Table 1 Summary of selected literature (WLE = wide local excision; RT = radiotherapy; Fx = fraction).

From: Case report and summary of literature: giant perineal keloids treated with post-excisional radiotherapy

*Author*	*Subset*	*Pts.*	*# Lesions*	*Technique*	*Response rate(%)*	*Total dose (Gy)*	*Fx size (Gy)*	*Notes/findings*
Arnold[13]	All	155	179	Superficial X-rays		10–30	2–7	Historical series demonstrates results of RT without surgery
	RT only		67	"	81	10–30	2–7
	WLE + RT		52	"	79	10–30	2–7
Chaudhry[14]	WLE + RT	36	-	Superficial X-rays	97	18	3	Series are earlobe keloids only.
Borok[15]	WLE + RT	250	393	Superficial X-rays	98	4–16	varied	Excellent cosmetic results in 92% of pts; recommended 12 Gy in 3 fx.
Doornbos[3]	RT alone/WLE + RT	203	278	Superficial X-rays	74	4.5–18	varied	Risk of failure necessitates total dose of at least 9 Gy. 15 pts got definitive RT. 9 Gy resulted in 70.4% control rate vs. 36.4% with 6 Gy.
Lo[16]	WLE + RT	199	354	Electrons	-	2–20	1	Single fraction regimen; local control of 87% receiving doses of 9 Gy or greater, vs 43% of 21 receiving less than 9 Gy, though non-significant statistically.
Kovalic[17]	WLE + RT	75	113	Superficial X-rays	73	10–20	1–5	Mixed treatment cohort; no need to give RT within 24 hours
Levy[18]	WLE + RT	37	-	Superficial X-rays	88	15–18	5–6	4/37 pts exhibited "fair or poor results"
Enhamre[19]	WLE + RT	47	62	Superficial X-rays	88	10–15	1–3	No statistical difference in pts. treated 3 vs 14 days post-excision.
Ogawa[20]	WLE + RT	129	147	electrons	67	15	5	Numerically large series with single dose protocol
Klumpar[21]	WLE + RT	83	126	Mixed	78			Study demonstrates electron beam offers no advantage over orthovoltage therapy
			73	Orthovoltage X-rays	85
			53	electrons	79
Maarouf[9]	WLE + RT	100	134	electrons	84	9–15	3–5
Malaker[22]	RT alone	64	86	Superficial X-rays/electrons	97	37.5	5	All pts had unresectable keloids; 63% of patients were pleased with treatment outcome
Ragoowansi[12]	WLE + RT	80	80	Superficial X-rays	84	10	1	100% control at 4 weeks follow-up; 91% relapse free at 1 yr; 84% relapse free at 5-years.
Sallstrom[23]	WLE + RT	124	-	Superficial X-rays	92	18	3	At 24 months 93% of patients found therapy worthwhile.
Sclafani[8]	WLE + RT	16	-	Superficial X-rays	88	7–10	1	RT arm of randomized trial vs. corticosteroid injection; greater compliance and ease of treatment with RT.

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ISSN: 1471-5945

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