Fig. 5
From: Elucidating mechanistic insights into drug action for atopic dermatitis: a systems biology approach
Pathways perturbed by BM and PC and their role in the action of these drugs. Solid lines depict activation or stimulation while the dotted lines represent inhibition. Colors of the lines denote known mechanism (black) and unknown mechanism (red). Colors of the gene names denote downregulation (green) and upregulation (red). This clearly shows that BM has a larger impact on inflammation than PC. But it is also evident that, unlike PC, BM negatively affects the skin barrier functions