Table 2 Key findings from our analysis: Genes and pathways perturbed by PC
From: Elucidating mechanistic insights into drug action for atopic dermatitis: a systems biology approach
Gene/Pathway | Role in skin pathways | Impact derived from eSkIN |
|---|---|---|
TGF-β | Plays important role in inflammation via SMADs, and regulates IFNG, IL2, CCL4, CXCL2 and MMP2 that are involved in T-cell chemotaxis and B-cell maturation | Downregulated after treatment with PC, thus contributes towards anti-inflammatory effect. |
IL13 receptor (IL13RA2) | Important regulator of chemokines through JAK-STAT pathway | Downregulated after treatment with PC, thus contributes towards anti-inflammatory effect. |
LOR, FLG, TGM5 and CDSN | Important skin barrier proteins | Upregulated after treatment with PC, thus contributes towards restoration of barrier functions. |