Table 1 Patient-reported outcome measures used in RELIEVE-AD
Questionnaires | Items (#) | Item content | Response options | Recall period | Score ranging and direction definition |
|---|---|---|---|---|---|
Atopic Dermatitis Control Tool (ADCT) | 6 | Overall severity of symptoms Days with intense episodes of itching Intensity of bothersomeness Problem with sleep Impact on daily activities Impact on mood or emotions | None, Mild, Moderate, Severe, Very severe Not at all, 1–2 days/nights, 3–4 days/nights, 5–6 days/nights, Every day/Every night Not at all, A little, Moderately, Very/A lot, Extremely | Past week | Item scores ranging from 0 to 4 Total score ranging from 0 (i.e., best disease control) to 24 (i.e., worst disease control) ADCT total score < 7 is considered as AD controlled, whereas ≥7 is considered AD is not controlled |
Skin pain NRS | 1 | Overall skin pain or soreness | NA | Past week | Scores ranging from 0 to 10 0 = No skin pain or soreness 10 = Worst skin pain or soreness |
Patient Global Assessment of Disease (PGAD) overall well-being | 1 | AD-related overall well-being | Excellent, Very good, Good, Fair, Poor | Past week | NA |
Dermatology Life Quality Index (DLQI) | 10 | Itch, pain, stinging symptoms Embarrassment Activities of daily living Everyday life (clothes to wear) Social life Sport activities Work and professional life Relationships Intimate life Treatment on everyday life | Very much, A lot, A little, Not at all | Past week | Total score ranging from 0 (i.e., no effect on patient’s life) to 30 (i.e., largest effect on patient’s life) Bands meaning: 0–1 = no effect at all on patient’s life 2–5 = small effect on patient’s life 6–10 = moderate effect on patient’s life 11–20 = very large effect on patient’s life 21–30 = extremely large effect on patient’s life |
Work Productivity and Activity Impairment - Atopic Dermatitis (WPAI-AD) | 6 | Absenteeism Presenteeism Total work impairment Total activity impairment | Multiple formats: Dichotomous Yes/No; NRS; number of hours | Past 7 days | Total score ranging from 0% impairment to 100% impairment |