Table 2 Best frontal- and occipital-specific biological pathways enriched for differential eGenes
From: Mapping of cis-acting expression quantitative trait loci in human scalp hair follicles
Biological pathway | GeneSet | Frontal scalp | Occipital scalp | ||||
|---|---|---|---|---|---|---|---|
n | Fold value | P | n | Fold value | P | ||
Frontal scalp eQTLs | |||||||
 Activation of Chaperones by ATF6-alpha | 9 | 3 | 21.85 | 2.78E-04 | 0 | 0.01 | 1 |
 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate | 3 | 2 | 43.68 | 6.92E-04 | 0 | 0.01 | 1 |
 Pyruvate metabolism and Citric Acid (TCA) cycle | 31 | 4 | 8.46 | 1.22E-03 | 0 | 0.01 | 1 |
 Arginine degradation I (arginase pathway) | 4 | 2 | 32.78 | 1.37E-03 | 0 | 0.01 | 1 |
 Proline biosynthesis II (from arginine) | 5 | 2 | 26.24 | 2.26E-03 | 0 | 0.01 | 1 |
 Arginine degradation VI (arginase 2 pathway) | 6 | 2 | 21.87 | 3.36E-03 | 0 | 0.01 | 1 |
 Vitamin C (ascorbate) metabolism | 6 | 2 | 21.87 | 3.36E-03 | 0 | 0.01 | 1 |
 Dolichyl-diphosphooligosaccharide biosynthesis | 7 | 2 | 18.75 | 4.65E-03 | 0 | 0.01 | 1 |
 Signaling events mediated by HDAC Class I | 113 | 6 | 3.48 | 7.84E-03 | 1 | 0.51 | 8.66E-01 |
 Signaling events mediated by HDAC Class II | 38 | 4 | 6.90 | 2.62E-03 | 1 | 1.51 | 4.91E-01 |
 BMP receptor signaling | 226 | 9 | 2.61 | 8.19E-03 | 5 | 1.26 | 3.66E-01 |
 Amino acid synthesis and interconversion (transamination) | 10 | 3 | 19.67 | 3.92E-04 | 1 | 5.74 | 1.63E-01 |
Occipital scalp eQTLs | |||||||
 BARD1 signaling events | 29 | 1 | 2.28 | 3.61E-01 | 4 | 7.86 | 1.57E-03 |
 G0 and Early G1 | 21 | 0 | 0.01 | 1 | 3 | 8.15 | 5.66E-03 |
 TGFBR | 125 | 4 | 2.10 | 1.25E-01 | 7 | 3.19 | 6.64E-03 |
 VEGF and VEGFR signaling network | 1301 | 27 | 1.36 | 6.57E-02 | 35 | 1.53 | 8.04E-03 |