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Table 2 Best frontal- and occipital-specific biological pathways enriched for differential eGenes

From: Mapping of cis-acting expression quantitative trait loci in human scalp hair follicles

Biological pathway GeneSet Frontal scalp Occipital scalp
n Fold value P n Fold value P
Frontal scalp eQTLs
 Activation of Chaperones by ATF6-alpha 9 3 21.85 2.78E-04 0 0.01 1
 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate 3 2 43.68 6.92E-04 0 0.01 1
 Pyruvate metabolism and Citric Acid (TCA) cycle 31 4 8.46 1.22E-03 0 0.01 1
 Arginine degradation I (arginase pathway) 4 2 32.78 1.37E-03 0 0.01 1
 Proline biosynthesis II (from arginine) 5 2 26.24 2.26E-03 0 0.01 1
 Arginine degradation VI (arginase 2 pathway) 6 2 21.87 3.36E-03 0 0.01 1
 Vitamin C (ascorbate) metabolism 6 2 21.87 3.36E-03 0 0.01 1
 Dolichyl-diphosphooligosaccharide biosynthesis 7 2 18.75 4.65E-03 0 0.01 1
 Signaling events mediated by HDAC Class I 113 6 3.48 7.84E-03 1 0.51 8.66E-01
 Signaling events mediated by HDAC Class II 38 4 6.90 2.62E-03 1 1.51 4.91E-01
 BMP receptor signaling 226 9 2.61 8.19E-03 5 1.26 3.66E-01
 Amino acid synthesis and interconversion (transamination) 10 3 19.67 3.92E-04 1 5.74 1.63E-01
Occipital scalp eQTLs
 BARD1 signaling events 29 1 2.28 3.61E-01 4 7.86 1.57E-03
 G0 and Early G1 21 0 0.01 1 3 8.15 5.66E-03
 TGFBR 125 4 2.10 1.25E-01 7 3.19 6.64E-03
 VEGF and VEGFR signaling network 1301 27 1.36 6.57E-02 35 1.53 8.04E-03
  1. eQTLs expression quantitative trait loci, GeneSet number of total genes in pathway term, n number of genes from the study overlapping the pathway term, P p-vlaue