Elias PM. Epidermal lipids, barrier function, and desquamation. J Invest Dermatol. 1983;80:44s–9s.
Article
CAS
PubMed
Google Scholar
Proksch E, Holleran WM, Menon GK, Elias PM, Feingold KR. Barrier function regulates epidermal lipid and DNA synthesis. Br J Dermatol. 1993;128:473–82.
Article
CAS
PubMed
Google Scholar
Breiden B, Sandhoff K. The role of sphingolipid metabolism in cutaneous permeability barrier formation. Biochim Biophys Acta. 2014;1841:441–52.
Article
CAS
PubMed
Google Scholar
van Smeden J, Hoppel L, van der Heijden R, Hankemeier T, Vreeken RJ, Bouwstra JA. LC/MS analysis of stratum corneum lipids: ceramide profiling and discovery. J Lipid Res. 2011;52:1211–21.
Article
PubMed
PubMed Central
CAS
Google Scholar
Motta S, Monti M, Sesana S, Caputo R, Carelli S, Ghidoni R. Ceramide composition of the psoriatic scale. Biochim Biophys Acta. 1993;1182:147–51.
Article
CAS
PubMed
Google Scholar
Masukawa Y, Narita H, Shimizu E, Kondo N, Sugai Y, Oba T, et al. Characterization of overall ceramide species in human stratum corneum. J Lipid Res. 2008;49:1466–76.
Article
CAS
PubMed
Google Scholar
Jia ZX, Zhang JL, Shen CP, Ma L. Profile and quantification of human stratum corneum ceramides by normal-phase liquid chromatography coupled with dynamic multiple reaction monitoring of mass spectrometry: development of targeted lipidomic method and application to human stratum corneum of different age groups. Anal Bioanal Chem. 2016;408:6623–36.
Article
CAS
PubMed
Google Scholar
Ishikawa J, Narita H, Kondo N, Hotta M, Takagi Y, Masukawa Y, et al. Changes in the ceramide profile of atopic dermatitis patients. J Invest Dermatol. 2010;130:2511–4.
Article
CAS
PubMed
Google Scholar
Koyano S, Hatamochi A, Yamazaki S, Ishikawa J, Kitahara T, Narita H, et al. Psoriasis patients have abnormal ceramide profile in stratum corneum. Nishinihon J Dermatol. 2010;72:494–9.
Article
Google Scholar
Imokawa G, Abe A, Jin K, Higaki Y, Kawashima M, Hidano A. Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? J Invest Dermatol. 1991;96:523–6.
Article
CAS
PubMed
Google Scholar
Di Nardo A, Wertz P, Giannetti A, Seidenari S. Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Derm Venereol. 1998;78:27–30.
Article
PubMed
Google Scholar
Farwanah H, Raith K, Neubert RH, Wohlrab J. Ceramide profiles of the uninvolved skin in atopic dermatitis and psoriasis are comparable to those of healthy skin. Arch Dermatol Res. 2005;296:514–21.
Article
CAS
PubMed
Google Scholar
Groen D, Poole DS, Gooris GS, Bouwstra JA. Investigating the barrier function of skin lipid models with varying compositions. Eur J Pharm Biopharm. 2011;79:334–42.
Article
CAS
PubMed
Google Scholar
Bouwstra JA, Gooris GS. The lipid organisation in human stratum corneum and model systems. Open Dermatol J. 2010;4:10–3.
CAS
Google Scholar
Janssens M, van Smeden J, Puppels GJ, Lavrijsen AP, Caspers PJ, Bouwstra JA. Lipid to protein ratio plays an important role in the skin barrier function in patients with atopic eczema. Br J Dermatol. 2014;170:1248–55.
Article
CAS
PubMed
Google Scholar
Joo KM, Hwang JH, Bae S, Nahm DH, Park HS, Ye YM, et al. Relationship of ceramide-, and free fatty acid-cholesterol ratios in the stratum corneum with skin barrier function of normal, atopic dermatitis lesional and non-lesional skins. J Dermatol Sci. 2015;77:71–4.
Article
CAS
PubMed
Google Scholar
Ishikawa J, Shimotoyodome Y, Ito S, Miyauchi Y, Fujimura T, Kitahara T, et al. Variations in the ceramide profile in different seasons and regions of the body contribute to stratum corneum functions. Arch Dermatol Res. 2013;305:151–62.
Article
PubMed
Google Scholar
Ishikawa J, Yoshida H, Ito S, Naoe A, Fujimura T, Kitahara T, et al. Dry skin in the winter is related to the ceramide profile in the stratum corneum and can be improved by treatment with a Eucalyptus extract. J Cosmet Dermatol. 2013;12:3–11.
Article
PubMed
Google Scholar
Mutanu Jungersted J, Hellgren LI, Høgh JK, Drachmann T, Jemec GB, Agner T. Ceramides and barrier function in healthy skin. Acta Derm Venereol. 2010;90:350–3.
Article
PubMed
CAS
Google Scholar
Masukawa Y, Narita H, Sato H, Naoe A, Kondo N, Sugai Y, et al. Comprehensive quantification of ceramide species in human stratum corneum. J Lipid Res. 2009;50:1708–19.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ohno Y, Nakamichi S, Ohkuni A, Kamiyama N, Naoe A, Tsujimura H, et al. Essential role of the cytochrome P450 CYP4F22 in the production of acylceramide, the key lipid for skin permeability barrier formation. Proc Natl Acad Sci U S A. 2015;112:7707–12.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol. 1959;37:911–7.
Article
CAS
PubMed
Google Scholar
Ekanayake-Mudiyanselage S, Aschauer H, Schmook FP, Jensen JM, Meingassner JG, Proksch E. Expression of epidermal keratins and the cornified envelope protein involucrin is influenced by permeability barrier disruption. J Invest Dermatol. 1998;111:517–23.
Article
CAS
PubMed
Google Scholar
Kunii T, Hirao T, Kikuchi K, Tagami H. Stratum corneum lipid profile and maturation pattern of corneocytes in the outermost layer of fresh scars: the presence of immature corneocytes plays a much more important role in the barrier dysfunction than do changes in intercellular lipids. Br J Dermatol. 2003;149:749–56.
Article
CAS
PubMed
Google Scholar
Jensen JM, Pfeiffer S, Akaki T, Schröder JM, Kleine M, Neumann C, et al. Barrier function, epidermal differentiation, and human beta-defensin 2 expression in tinea corporis. J Invest Dermatol. 2007;127:1720–7.
Article
CAS
PubMed
Google Scholar
Kim D, Lee NR, Park SY, Jun M. K. Lee, S. Kim, et al. as in atopic dermatitis, nonlesional skin in allergic contact dermatitis displays abnormalities in barrier function and ceramide content. J Invest Dermatol. 2017;137:748–50.
Article
CAS
PubMed
Google Scholar
Danso MO, van Drongelen V, Mulder A, van Esch J, Scott H, van Smeden J, et al. TNF-alpha and Th2 cytokines induce atopic dermatitis-like features on epidermal differentiation proteins and stratum corneum lipids in human skin equivalents. J Invest Dermatol. 2014;134:1941–50.
Article
CAS
PubMed
Google Scholar
Pierard GE. EEMCO guidance for the assessment of skin colour. J Eur Acad Dermatol Venereol. 1998;10:1–11.
CAS
PubMed
Google Scholar
Jiang ZX, DeLaCruz J. Appearance benefits of skin moisturization. Skin Res Technol. 2011;17:51–5.
Article
PubMed
Google Scholar
Anderson RR, Parrish JA. The optics of human skin. J Invest Dermatol. 1981;77:13–9.
Article
CAS
PubMed
Google Scholar
Briot A, Deraison C, Lacroix M, Bonnart C, Robin A, Besson C, et al. Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome. J Exp Med. 2009;206:1135–47.
Article
CAS
PubMed
PubMed Central
Google Scholar
Oyoshi MK, He R, Kumar L, Yoon J, Geha RS. Cellular and molecular mechanisms in atopic dermatitis. Adv Immunol. 2009;102:135–226.
Article
CAS
PubMed
Google Scholar
Sawada E, Yoshida N, Sugiura A, Imokawa G. Th1 cytokines accentuate but Th2 cytokines attenuate ceramide production in the stratum corneum of human epidermal equivalents: an implication for the disrupted barrier mechanism in atopic dermatitis. J Dermatol Sci. 2012;68:25–35.
Article
CAS
PubMed
Google Scholar
Yoshida N, Sawada E, Imokawa G. A reconstructed human epidermal keratinization culture model to characterize ceramide metabolism in the stratum corneum. Arch Dermatol Res. 2012;304:563–77.
Article
CAS
PubMed
Google Scholar
t'Kindt R, Jorge L, Dumont E, Couturon P, David F, Sandra P, et al. Profiling and characterizing skin ceramides using reversed-phase liquid chromatography-quadrupole time-of-flight mass spectrometry. Anal Chem. 2012;84:403–11.
Article
CAS
PubMed
Google Scholar
Bachelor M, Binder RL, Cambron RT, Kaczvinsky JR, Spruell R, Wehmeyer KR, et al. Transcriptional profiling of epidermal barrier formation in vitro. J Dermatol Sci. 2014;73:187–97.
Article
PubMed
Google Scholar
Omae F, Miyazaki M, Enomoto A, Suzuki M, Suzuki Y, Suzuki A. DES2 protein is responsible for phytoceramide biosynthesis in the mouse small intestine. Biochem J. 2004;379:687–95.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mizutani Y, Mitsutake S, Tsuji K, Kihara A, Igarashi Y. Ceramide biosynthesis in keratinocyte and its role in skin function. Biochimie. 2009;91:784–90.
Article
CAS
PubMed
Google Scholar
Mizutani Y, Kihara A, Igarashi Y. Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation. FEBS Lett. 2004;563:93–7.
Article
CAS
PubMed
Google Scholar
Mao C, Obeid LM. Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate. Biochim Biophys Acta. 1781;2008:424–34.
Google Scholar
Sun W, Xu R, Hu W, Jin J, Crellin HA, Bielawski J, et al. Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes. J Invest Dermatol. 2008;128:389–97.
Article
CAS
PubMed
Google Scholar